Androgen injection

Erectile dysfunction is not uncommon after radical prostatectomy and men who undergo ADT in addition to this are likely to show further decline in their ability to engage in penetrative intercourse, as well as their desire to do so. [13] A study looking at the differences of using GnRH-A (and androgen suppressant) or an orchiectomy report differences in sexual interest, the experience of erections, and the prevalence of participating in sexual activity. Men reporting no sexual interest increased from % to % after orchiectomy, and from % to % after GnRH-A; men who experienced no erections increased from % to %; and men who did not report engaging in sexual activity increased from % to % after orchiectomy and % to %. [14] This study suggests that the GnRH-A and orchiectomy had similar effects on sexual functioning. A vicious cycle whereby lowering testosterone levels leads to decreased sexual activity, which in turn cause both free and total testosterone levels to decline even further. [12] This demonstrates the importance of androgens for maintaining sexual structures and functions. [12] [15]

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate , seminal vesicles , penis , and scrotum ; development of male hair distribution, such as beard , pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen , sodium, potassium , and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism . Nitrogen balance is improved only when there is sufficient intake of calories and protein.

DHT is a potent agonist of the AR, and is in fact the most potent known endogenous ligand of the receptor. It has an affinity (K d ) of to  nM for the human AR, which is about 2- to 3-fold higher than that of testosterone (K d = to  nM) [43] and 15–30 times higher than that of adrenal androgens . [44] In addition, the dissociation rate of DHT from the AR is 5-fold slower than that of testosterone. [45] The EC 50 of DHT for activation of the AR is  nM, which is about 5-fold stronger than that of testosterone (EC 50 =  nM). [46] In bioassays , DHT has been found to be - to 10-fold more potent than testosterone. [43]

The most commonly reported side effects in men were related to a decrease in testosterone levels. Adverse effects that were reported in advanced prostate cancer clinical trials of ZOLADEX -mg implant were hot flashes, sexual dysfunction, decreased erections, lower urinary tract symptoms, lethargy, pain that worsened in the first 30 days of ZOLADEX use, swelling due to accumulation of fluid, upper respiratory infection, rash, and sweating. Among patients who received ZOLADEX -mg implant, the most commonly reported adverse effects were hot flashes, generalized pain, increased breast size (gynecomastia), pelvic pain, and bone pain.

PREGNYL® (chorionic gonadotropin for injection USP) is a highly purified pyrogen-free preparation obtained from the urine of pregnant females. It is standardized by a biological assay procedure. It is available for intramuscular injection in multiple dose vials containing 10,000 USP units of sterile dried powder with 5 mg monobasic sodium phosphate and mg dibasic sodium phosphate. If required, pH is adjusted with sodium hydroxide and/or phosphoric acid. Each package also contains a 10-mL vial of solvent containing: water for injection with % sodium chloride and % BENZYL ALCOHOL, WHICH IS NOT FOR USE IN NEWBORNS. If required, pH is adjusted with sodium hydroxide and/or hydrochloric acid.

Androgen injection

androgen injection

The most commonly reported side effects in men were related to a decrease in testosterone levels. Adverse effects that were reported in advanced prostate cancer clinical trials of ZOLADEX -mg implant were hot flashes, sexual dysfunction, decreased erections, lower urinary tract symptoms, lethargy, pain that worsened in the first 30 days of ZOLADEX use, swelling due to accumulation of fluid, upper respiratory infection, rash, and sweating. Among patients who received ZOLADEX -mg implant, the most commonly reported adverse effects were hot flashes, generalized pain, increased breast size (gynecomastia), pelvic pain, and bone pain.

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