The results showed that heart rate wasn’t affected by either caffeine alone or any combination of caffeine and geranamine. But blood pressure and RPP were higher, depending on the dosage. Specifically, systolic blood pressure rose by 20 percent and diastolic blood pressure went up 17 percent, along with a 9 percent increase in RPP, with the combination of 250 milligrams of caffeine and 75 milligrams of geranamine an hour after the subjects took it. The catecholamines, epinephrine and norepinephrine, were not affected. What’s interesting about this is that unlike ephedrine, the catecholamines were not involved in the rise in blood pressure. Nor was the heart rate affected. So what did cause blood pressure to go up with the greatest dose? That remains for future research to determine.
DHEA may cause side effects related to other hormones. Women may experience symptoms such as oily skin, increased unnatural hair growth, a deep voice, irregular periods, smaller breast size, and increased genital size. Men may experience breast tenderness, urinary urgency, aggression, or reduced size of the testes. Other side effects that may occur in either sex include acne, sleep problems, headache, nausea, skin itching, and mood changes. DHEA may also affect levels of other hormones, insulin, and cholesterol. Safety information is lacking on the long-term effects of DHEA. DHEA may increase the risk of prostate, breast, and ovarian cancers. It is not suggested for regular use without a health professional's care.