Another early double-blind, placebo-controlled study of 320mg Permixon® daily found significant improvement in many symptoms of BPH over placebo.  A later retrospective study in men with urinary symptoms caused by BPH (no prostatic cancer and PSA less than 10ng/mL) given 320mg saw palmetto (Permixon®) for six months confirmed this.  It found an improvement in urinary symptoms when saw palmetto was used alone as well as when used alongside an alpha-blocker, although saw palmetto alone showed better responses on mean void volume and intermittence in urinary flow while combination therapy had a more rapid improvement in maximum flow. 
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