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Drugs that increase metabolism can help in terms of weight loss, but they're only effective for as long as a person continues taking them. Once a particular drug is discontinued, a person's metabolism rate will go back to where it was at the start. Also of concern is how stimulant ingredients, in particular, increase the body's hormone production. When used for prolonged periods of time, the body's ability to produce hormones naturally may decline, which can lead to other problems. Combining proper diet and regular exercise with a metabolism-boosting drug will help the body maintain any increases in metabolism.