Unintentional overdose of an opioid can usually be managed expectantly; however, if partial reversal is necessary, very low-dose naloxone (formerly Narcan) can be quickly administered by giving - to -mg (or mcg per kg) intravenous or intramuscular boluses every three to five minutes, titrated to respiratory rate or mental status (mix one mg per mL ampule of naloxone with saline to make 10 mL, which equals mg per mL). 27 Continued close monitoring is necessary because duration of opioid effect may outlast naloxone.
There were three 7 to 9 week, double-blind, placebo-controlled, parallel group studies in children and adolescents (aged 6-17 years) with Attention-Deficit Hyperactivity Disorder (ADHD). Two of the studies were flexible-dose studies (up to 425 mg/day), and the third was a fixed-dose study (340 mg/day for patients <30 kg and 425 mg/day for patients ≥30 kg). Although these studies showed statistically significant differences favoring Modafinil over placebo in reducing ADHD symptoms as measured by the ADHD-RS (school version), there were 3 cases of serious rash including one case of possible SJS among 933 patients exposed to Modafinil in this program. Modafinil is not approved for use in treating ADHD.