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g) Using a value of x 104 L/mol for the association constant of albumin for T, the calculated albumin-bound T varied from nmol/L (40 g/L albumin) to nmol/L (50 g/L albumin). In view of the relatively unimportant changes in FT, when the albumin concentration varies by as much as 25%, it was concluded that for routine purposes FT could be calculated assuming an albumin concentration of 43 g/L ( x 10-4 mol/L) if one is not dealing with sera from patients with marked abnormalities in plasma protein composition, such as in nephrotic syndrome or cirrhosis of the liver, or with sera obtained during pregnancy, in which cases the actual albumin concentration should be taken into account.
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