This may surprise you, but virtually nothing bad happens after T replacement therapy begins, at least not in the vast majority of patients. No negative side effects occur to the liver (remember, all the bad things took place as a result of using the 17-alpha alkylated stuff you generally get from dealers or overseas markets). No definite negative cardiovascular effects have been noted. Even the prostate, long regarded as the first organ to take the plunge after using "evil" steroids, is relatively safe. The truth is that it's pretty much accepted now that prostate growth occurs through the action of 5-alpha DHT and that these effects are related to things that happen exclusively within the prostate and are not influenced by serum concentrations of T or 5-alpha DHT. Furthermore, estrogens are believed to be the true culprit by some. T therapy increases the prostate size slightly, but only to the point of normalcy. If any doubt of this remains, a recent study (Hajjar, 1997) tracked men in their seventies who had been receiving T replacement therapy for two years. The treatment group experienced less prostate growth than the control group.